Silymarin: A Phytoconstituent with Significant Therapeutic Potential-A Narrative Review

Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum maria-num L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has been used to treat several physiological disorders. The objective of this manuscript was to review the therapeutic prospective of silymarin due to its ability to treat several physiological disorders. The da-tabases such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews published related to the title. The discussion is focused on the immunomodulatory, chemopreventive, and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In addition, the review discusses the different therapeutic potentials of silymarin such as the management of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenera-tive disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Si-lymarin had good potential for the safe and effective treatment of numerous metabolic and dermatological disorders. © 2023 Bentham Science Publishers.

An Overview of Investigational Drugs for the Treatment of Covid-19

SARS-CoV-2 has been emerged from Wuhan in China and has now shacked out more than 200 Countries and territories all over the world. World’s best scientists are contributing and endeavouring to find drugs, immuno-modulators and vaccines for the treatment of COVID-19. SARS-CoV-2 virus is a betacoronavirus and positive-stranded RNA virus that originates from the Coronaviridae family. The most important structural proteins of SARS-CoV-2 are spike trimeric (S) protein, membrane (M) protein, envelop (E) protein and the nucleocapsid (N) protein. The SARS-CoV-2 begins its life cycle, when the S protein binds with the host cells receptor ACE2 (angiotensin-converting enzyme 2). The viral protein(M) and genome (Protein-N) RNA eventually get assembled into virions (with Protein-S and HE), Endoplasmic reticulum and Golgi apparatus. According to the various research reports, there aremore than 50 drugs, immunomodulators and vaccines that may be effective against COVID-19. Some drugs had shown the in vitro activity against MN1 -https://media.proquest.com/media/hms/PFT/1/Dn72N?_a=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%3D%3D&_s=zUuGTksgyVFKqrcRhToSnSU0YCM%3D ERS-CoV, SARS-CoV and SARS-CoV-2. The aim of this review is to highlight the properties,structure, life cycle of SARS-CoV-2 and description of the agents which show potential efficacy against SARS-CoV-2.

Possible potential treatment strategies against novel coronavirus sars-cov-2

SARS-CoV-2 initiated as an outbreak from Wuhan in China in December 2019, and spreads globally. SARS-CoV-2 is a positively stranded RNA virus which belongs to the category of beta coronavirus of the family Coronaviridae. This novel Corona virus structurally resembles with the previous SARS-CoV which spread in 2002. Many treatment strategies can be effective against this novel corona virus. This novel corona virus SARS-CoV-2 resembles in features with another virus, SARS-CoV, which spread in 2002. Taking this in account the therapeutic agents which was used for the prevention of SARS-CoV can be used as potential agent for prevention of this novel corona virus. The main focus of the present study was to review the application of various chemotherapeutic agents, anti-viral or non-anti-viral agents for the treatment of SARS-CoV-2. The study also covers potential immunotherapy strategies, vaccine development, herbal formulations and nutrient combination as immunity boosters to combat with this pandemic disease. © 2020, Advanced Scientific Research. All rights reserved.